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US9109033B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9109033-B2 |
| Application number | US-201314135292-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 19, 2013 |
| Priority date | Dec 12, 1997 |
| Publication date | Aug 18, 2015 |
| Grant date | Aug 18, 2015 |
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Abstract
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A method of modulating immune response in an animal is disclosed. Such a method interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells present the antigen on their surfaces, inducing maturation of the immature dendritic cells ex vivo, and contacting the mature dendritic cells ex vivo with a modulator comprising TRANCE, conservative variants thereof, fragments thereof, analogs or derivatives thereof, or a fusion protein comprising the amino acid sequence of TRANCE, conservative variants thereof, or fragments thereof. After contacting the modulator ex vivo, the mature dendritic cells are introduced into the animal. As a result, immune response in the animal towards the antigen is modulated relative to the immune response against the antigen in an animal in which dendritic cells did not interact with the antigen ex vivo, and did not contact a modulator ex vivo. Preferably, the method of the present invention results in increasing immune response towards the antigen in the animal.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of treating an immune system related condition in a subject, the method comprising administering an antibody or a binding fragment thereof to a subject in need thereof, wherein said antibody or binding fragment thereof is specific for a human form of TRANCE and not a mouse form of TRANCE and binds to a human TRANCE polypeptide, wherein said polypeptide comprises the amino acid sequence of SEQ ID NO:2. 2. The method of claim 1 , w…
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Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
- C07K16/2875Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
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- What does patent US9109033B2 cover?
- A method of modulating immune response in an animal is disclosed. Such a method interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells present the antigen on their surfaces, inducing maturation of the immature dendritic cells ex vivo, and contacting the mature dendritic cells ex vivo with a modulator comprising TRANCE, conservative …
- Who is the assignee on this patent?
- Univ Rockefeller
- What technology area does this patent fall under?
- Primary CPC classification C07K16/2875. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Aug 18 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).