Dendrimers for genomic analysis methods and compositions
US-2024301515-A1 · Sep 12, 2024 · US
Production of carrier-peptide conjugates using chemically reactive unnatural amino acids
US9109022B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9109022-B2 |
| Application number | US-201314065111-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 28, 2013 |
| Priority date | Dec 10, 2008 |
| Publication date | Aug 18, 2015 |
| Grant date | Aug 18, 2015 |
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Abstract
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Provided are methods of making carrier polypeptide that include incorporating a first unnatural amino acid into a carrier polypeptide variant, incorporating a second unnatural amino acid into a target polypeptide variant, and reacting the first and second unnatural amino acids to produce the conjugate. Conjugates produced using the provided methods are also provided. In addition, orthogonal translation systems in methylotrophic yeast and methods of using these systems to produce carrier and target polypeptide variants comprising unnatural amino acids are provided.
First claim
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What is claimed is: 1. A carrier polypeptide-target polypeptide conjugate comprising: a carrier polypeptide domain comprising a first unnatural amino acid residue, wherein the carrier polypeptide domain comprises an antibody or antibody fragment; and, a target polypeptide domain comprising a second unnatural amino acid residue; wherein the carrier polypeptide domain and target polypeptide domain are conjugated together through the first and second unnatural amino acid residues…
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- What does patent US9109022B2 cover?
- Provided are methods of making carrier polypeptide that include incorporating a first unnatural amino acid into a carrier polypeptide variant, incorporating a second unnatural amino acid into a target polypeptide variant, and reacting the first and second unnatural amino acids to produce the conjugate. Conjugates produced using the provided methods are also provided. In addition, orthogonal tra…
- Who is the assignee on this patent?
- Scripps Research Inst
- What technology area does this patent fall under?
- Primary CPC classification C07K19/00. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Aug 18 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).