Compositions and methods for increasing protein half-life in a serum
US-2019330370-A1 · Oct 31, 2019 · US
US9109020B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9109020-B2 |
| Application number | US-201313930070-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 28, 2013 |
| Priority date | Jul 31, 2003 |
| Publication date | Aug 18, 2015 |
| Grant date | Aug 18, 2015 |
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The invention concerns the use of human or humanized chimeric monoclonal antibodies which are produced in selected cell lines, said antibodies bringing about a high ADCC activity as well as a high secretion of cytokines and interleukins, for treating underpopulations of so-called weak-response patients exhibiting CD16 FCGR3A-158F homozygote or FCGR3A-158V/F heterozygote polymorphism.
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The invention claimed is: 1. A method for treating haemolytic disease of the Previously Presentedborn, Sezary Syndrome, chronic myeloid leukaemias, chronic lymphoid leukaemias (CLL-B), cancer, breast cancer, conditions related to the environment, infectious diseases, chronic fatigue syndrome (CFS), parasitic infections, or viral infections, comprising: administering a composition of antibodies specific to the condition to be treated to a patient homozygous for phenylalanine in pos…
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