Orally active leukemia inhibitory factor (lif) antagonists for the treatment of cancer
US-2024124515-A1 · Apr 18, 2024 · US
US9109004B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9109004-B2 |
| Application number | US-201113578500-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 8, 2011 |
| Priority date | Feb 10, 2010 |
| Publication date | Aug 18, 2015 |
| Grant date | Aug 18, 2015 |
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The invention relates to 17-hydroxy-17-pentafluoroethyl-estra-4,9(10)-dien-11-aryl derivatives of formula I with progesterone-antagonizing action and methods of production thereof, use thereof for the treatment and/or prevention of diseases and use thereof for producing medicinal products for the treatment and/or prevention of diseases, in particular uterine fibroids (myomata, uterine leiomyomata), endometriosis, heavy menstrual bleeding, meningiomata, hormone-dependent breast cancers and menopause-associated complaints or for fertility control and emergency contraception.
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The invention claimed is: 1. A compound of formula I in which R 1 stands either for a residue Y or for a phenyl ring substituted with Y, Y stands for a group R 2 and R 3 are identical or different and stand for hydrogen, an optionally —N(CH 3 ) 2 ,…
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