E-selectin antagonist compounds, compositions, and methods of use

Patent metadata

Field	Value
Publication number	US-9109002-B2
Application number	US-201214367561-A
Country	US
Kind code	B2
Filing date	Dec 21, 2012
Priority date	Dec 22, 2011
Publication date	Aug 18, 2015
Grant date	Aug 18, 2015

Abstract

Methods and compositions using E-selectin antagonists are provided for the treatment and prevention of diseases and disorders treatable by inhibiting binding of E-selectin to an E-selectin ligand. Described herein are E-selectin antagonists including, for example, glycomimetic compounds, antibodies, aptamers and peptides that are useful in methods for treatment of cancers, and treatment and prevention of metastasis, inhibiting infiltration of the cancer cells into bone marrow, reducing or inhibiting adhesion of the cancer cells to endothelial cells including cells in bone marrow, and inhibiting thrombus formation.

First claim

We claim the following:

1. A compound having the formula (I):

or a pharmaceutically acceptable salt, isomer, tautomer, hydrate or solvate thereof, wherein:
R 1 is C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 2 -C 8 alkynyl, C 1 -C 8 haloalkyl, C 2 -C 8 haloalkenyl or C 2 -C 8 haloalkynyl;
R 2 is a linker-non-glycomimetic moiety, wherein the non-glycomimetic moiety compr…

Assignees

• Glycomimetics Inc

Inventors

• Magnani John L
• Sarkar Arun K
• Baek Myung-Gi
• Anderson Iii Frank E
• Li Yanhong

Classifications

• A61P7/02

  Human Necessities · mapped topic

• A61P43/00

  Human Necessities · mapped topic

• A61P35/00

  Human Necessities · mapped topic

• A61P35/02

  Human Necessities · mapped topic

• A61P35/04

  Human Necessities · mapped topic