2,3-dihydrobenzo[b]thiophene derivatives as hypoxia inducible factor-2(alpha) inhibitors
US-12171741-B2 · Dec 24, 2024 · US
US9108978B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9108978-B2 |
| Application number | US-201214346646-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 21, 2012 |
| Priority date | Sep 23, 2011 |
| Publication date | Aug 18, 2015 |
| Grant date | Aug 18, 2015 |
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A new class of biotin protein ligase (BPL) inhibitors that have antibacterial activity against multiple Staphylococcus aureus isolates, including clinically important methicillin-resistant S. aureus (MRSA) are disclosed that are non-toxic.
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The claims defining the invention are as follows: 1. A compound of formula (I) wherein n is an integer from 1 to 10; R 1 is selected from the group consisting of: imidazole,…
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