Gpx4 inhibitors, pharmaceutical compositions thereof, and their use for treating gpx4-mediated diseases
US-2024246901-A1 · Jul 25, 2024 · US
US9108943B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9108943-B2 |
| Application number | US-201414308094-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 18, 2014 |
| Priority date | Jun 18, 2013 |
| Publication date | Aug 18, 2015 |
| Grant date | Aug 18, 2015 |
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The design, modeling, synthesis, biological evaluation, and photoaffinity labeling studies of a series of photoreactive potent and selective HDACs 1 and 2 benzamide based probes are disclosed herein.
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The invention claimed is: 1. A compound of formula (I): or a salt, hydrate or solvate thereof, wherein: X is selected from the group consisting of azido, phenyl and thiophenyl; each Y is independently selected from the group consisting of hydrogen, alkyl and substituted alkyl; and R 1 , R 2 and R 3 are independently selected from the group consis…
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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