A series of pyrrole derivatives and their preparation method and therapeutic use
US-2024327423-A1 · Oct 3, 2024 · US
US9108938B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9108938-B2 |
| Application number | US-201314050466-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 10, 2013 |
| Priority date | Oct 12, 2012 |
| Publication date | Aug 18, 2015 |
| Grant date | Aug 18, 2015 |
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The present invention is directed to novel cyclic amines which inhibit the P2X 7 receptor.
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What is claimed: 1. A compound of formula I wherein R 1 is pyrimidyl optionally substituted with one or more C 1-6 alkyl, halogen, hydroxy, C 1-4 fluoroalkyl, C 3-6 cycloalkyl, C 1-6 alkoxy, C 1-6 fluoroalkoxy, cyano or —SO 2 R 7 ; wherein R 2a and R 2b combine with the nitrogen to which they are attached to form piperazinyl, piperidinyl, morpholinyl, pyrrolidi…
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