Substituted [1,2,4]triazole and imidazole compounds
US-2015351399-A1 · Dec 10, 2015 · US
US9108933B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9108933-B2 |
| Application number | US-201414176841-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 10, 2014 |
| Priority date | May 25, 2007 |
| Publication date | Aug 18, 2015 |
| Grant date | Aug 18, 2015 |
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The present invention relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating c-Met associated cancers, in a subject in need thereof.
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What is claimed: 1. A method of treating a c-Met associated cancer in a subject, comprising administering to the subject an effective amount of a compound represented by formula (XVIII): or a tautomer or pharmaceutically acceptable salt thereof, wherein: R 1 is —OH, —SH, —NR 7 H, —OR 26 , —SR 26 , —NHR 26 , —O(CH 2 ) m OH, —O(CH 2 ) m SH, —O(CH 2 ) m NR 7 H, —S(CH 2…
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