Rosuvastatin calcium and process for producing intermediate thereof
US-2024360086-A1 · Oct 31, 2024 · US
US9108925B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9108925-B2 |
| Application number | US-79595706-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 24, 2006 |
| Priority date | Jan 28, 2005 |
| Publication date | Aug 18, 2015 |
| Grant date | Aug 18, 2015 |
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The present invention relates to a novel process for the manufacture of Grewe-diamine comprising the following step: hydrolyzing a compound of formula (II), wherein R is hydrogen or straight- or branched chain C1-4 alkyl, with an aqueous alkali or alkaline-earth metal hydroxide solution, characterized in that the hydrolysis is carried out in the presence of an organic solvent.
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The invention claimed is: 1. A process for the manufacture of Grewe-diamine with purity of at least 94% comprising: hydrolyzing a compound of the formula II wherein R is hydrogen or straight- or branched-chain C 1-4 alkyl, with an aqueous alkali or alkaline-earth metal hydroxide solution characterized in that the hydrolysis is carried out in the presence of an organic solve…
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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