Ror gamma modulators
US-2020024257-A1 · Jan 23, 2020 · US
Method for producing 3,4-disubstituted pyrrolidine derivative
US9108915B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9108915-B2 |
| Application number | US-201113880207-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 24, 2011 |
| Priority date | Oct 25, 2010 |
| Publication date | Aug 18, 2015 |
| Grant date | Aug 18, 2015 |
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Abstract
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The present invention provides an inexpensive and industrially advantageous method for producing an optically active form of an anti-(3S,4R)-3-alkylcarbamoyl-4-hydroxypyrrolidine derivative or it's enantiomer, which is a key intermediate for producing a high-quality optically active form of (3R,4S)-3-alkylaminomethyl-4-fluoropyrrolidine or it's enantiomer useful as an intermediate for producing pharmaceuticals. The present invention relates to a method for producing an optically active anti-(3S,4R)-4-hydroxypyrrolidine-3-carboxamide derivative, or it's enantiomer by carrying out asymmetric hydrogenation using an optically active catalyst of a 4-oxopyrrolidine-3-carboxamide derivative represented by the general formula (I). [in the formula (I), PG 1 represents a protective group for an amino group, and R 1 represents hydrogen, a C1 to C6 alkyl group which may be substituted, or a C3 to C8 cycloalkyl group which may be substituted].
First claim
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The invention claimed is: 1. A method for producing an optically active anti-4-hydroxypyrrolidine-3-carboxamide compound represented by formula (II) or its enantiomer, wherein PG 1 represents a protecting group for an amino group and R 1 represents hydrogen, a C1 to C6 alkyl group which may be substituted, or a C3 to C8 cycloalkyl group which may be substituted, the…
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Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
- C07D207/24Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US9108915B2 cover?
- The present invention provides an inexpensive and industrially advantageous method for producing an optically active form of an anti-(3S,4R)-3-alkylcarbamoyl-4-hydroxypyrrolidine derivative or it's enantiomer, which is a key intermediate for producing a high-quality optically active form of (3R,4S)-3-alkylaminomethyl-4-fluoropyrrolidine or it's enantiomer useful as an intermediate for producing…
- Who is the assignee on this patent?
- Araya Ichiro, Kiyota Koichi, Nagao Muneki, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification C07D207/24. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Aug 18 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).