Hydrazino 1H-imidazoquinolin-4-amines and conjugates made therefrom

Patent metadata

Field	Value
Publication number	US-9107958-B2
Application number	US-201214123718-A
Country	US
Kind code	B2
Filing date	Jun 1, 2012
Priority date	Jun 3, 2011
Publication date	Aug 18, 2015
Grant date	Aug 18, 2015

Abstract

1H-Imidazo[4,5-c]quinolin-4-amines substituted at the 1-position with a substituent bearing a hydrazinobenzamide or hydrazinonicotinamide, a salt thereof, or a protected hydrazinobenzamide or hydrazinonicotinamide and conjugates made from such compounds are disclosed. Pharmaceutical compositions containing the compound or the conjugate, methods of making a conjugate, and methods of use of the compounds or conjugates as immunomodulators for inducing cytokine biosynthesis in an animal and for vaccinating an animal are also disclosed.

First claim

What is claimed is:

1. A compound of formula:

wherein:
X is alkylene having up to 8 carbon atoms optionally interrupted or terminated by —O—;
R 2 is hydrogen, alkyl, alkoxyalkylenyl, alkylaminoalkylenyl, or hydroxyalkylenyl;
P is an amino group, a protected amino group, or NH 3 + Y − , wherein Y − is a counter anion;
A is CH or N;
R is halogen, hydroxyl, alky…

Assignees

• Wightman Paul D
• 3M Innovative Properties Co

Inventors

• Wightman Paul D

Classifications

• A61P31/18

  Human Necessities · mapped topic

• A61P37/02

  Human Necessities · mapped topic

• A61P37/04

  Human Necessities · mapped topic

• A61P31/06

  Human Necessities · mapped topic

• A61P31/12

  Human Necessities · mapped topic