Methods for treatment of cancer with an anti-tigit antagonist antibody
US-2024424092-A1 · Dec 26, 2024 · US
US9107956B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9107956-B2 |
| Application number | US-201314055581-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 16, 2013 |
| Priority date | Mar 12, 2007 |
| Publication date | Aug 18, 2015 |
| Grant date | Aug 18, 2015 |
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The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the small molecule drug not attached to the water-soluble oligomer.
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What is claimed is: 1. A compound of the following Formula wherein: X is a stable amide linkage; POLY is a poly(alkylene oxide) of between 1 and 30 monomers; and R 1 is benzyloxycarbonyl or 2-quinolylcarbonyl. 2. The compound of claim 1 , wherein R 1 is benzyloxycarbonyl. 3. The compound of claim 1 , wherein R 1 is 2-qui…
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