Compositions and methods for treating alzheimer's disease
US-2024376452-A1 · Nov 14, 2024 · US
US9107936B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9107936-B2 |
| Application number | US-201213983417-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 2, 2012 |
| Priority date | Feb 2, 2011 |
| Publication date | Aug 18, 2015 |
| Grant date | Aug 18, 2015 |
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The present invention concerns antagonists of the Golgi reassembly-stacking protein of 55 k Da (Grasp55), for use as a medicament, in particular for use in the treatment of cell adhesion molecules implicated diseases, notably, MCAM or JAMs implicated diseases. According to some embodiments, said antagonists of the Golgi reassembly-stacking protein of 55 k Da (Grasp55) may be used in the treatment of cancer, metastases, and inflammatory diseases. The present invention further provides methods for screening for compounds liable of treating or preventing such diseases.
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The invention claimed is: 1. A method for treating a patient suffering from a JAM-A or JAM-C implicated disease said method comprising the step of administering an effective amount of an antagonist of the Golgi reassembly-stacking protein of 55 kDa (Grasp55) to an individual in need thereof. 2. The method of claim 1 , wherein said JAM-A or JAM-C implicated disease is selected from the group consisting of cancer and an inflammatory disease. 3…
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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