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Compositions and methods of targeting apolipoprotein B for the reduction of apolipoprotein C-III
US9107933B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9107933-B2 |
| Application number | US-201013257260-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 16, 2010 |
| Priority date | Mar 16, 2009 |
| Publication date | Aug 18, 2015 |
| Grant date | Aug 18, 2015 |
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Abstract
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Disclosed herein are compositions and methods for lowering Apolipoprotein C-III (ApoC-III) in a subject in need thereof. Subjects in need of ApoC-III reduction include subjects with elevated ApoC-III levels, subjects with a condition associated with ApoC-III, subjects with diabetes, obese subjects and subjects with cardiovascular disease. Compositions to lower ApoC-III include compounds targeting Apolipoprotein B (ApoB) such as Mipomersen and other antisense compound targeting ApoB.
First claim
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What is claimed is: 1. A method of lowering plasma apolipoprotein C-III levels in a human subject, comprising: selecting a human subject with elevated apolipoprotein C-III levels or a condition associated with apolipoprotein C-III; and administering to said human subject a therapeutically effective amount of a compound comprising a modified oligonucleotide having 12-30 linked nucleosides, or a salt thereof, wherein said modified oligonucleotide is 100% complementary to a nucle…
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Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
- A61K31/7088Primary
Human Necessities · mapped topic
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- What does patent US9107933B2 cover?
- Disclosed herein are compositions and methods for lowering Apolipoprotein C-III (ApoC-III) in a subject in need thereof. Subjects in need of ApoC-III reduction include subjects with elevated ApoC-III levels, subjects with a condition associated with ApoC-III, subjects with diabetes, obese subjects and subjects with cardiovascular disease. Compositions to lower ApoC-III include compounds targeti…
- Who is the assignee on this patent?
- Sacks Frank M, Tribble Diane, Isis Pharmaceuticals Inc, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification A61K31/7088. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Aug 18 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).