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Dendritic cell targeting compositions and uses thereof
US9107858B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9107858-B2 |
| Application number | US-99950907-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 5, 2007 |
| Priority date | Dec 5, 2007 |
| Publication date | Aug 18, 2015 |
| Grant date | Aug 18, 2015 |
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Abstract
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The present invention provides compositions and methods for targeting dendritic cells of the immune system. In particular, the compositions comprise carbon nanoparticles, optionally magnetic carbon nanoparticles comprising iron, which are preferentially endocytosed by dendritic cells compared to macrophages when contacted with a biological sample. The nanoparticles of the present invention may be functionalized to enhance delivery of biomolecules to dendritic cells.
First claim
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What is claimed is: 1. A vaccine delivery system comprising: a carbon nanoparticle that is preferentially endocytosed by dendritic cells as compared to macrophages; and an antigenic protein or peptide conjugated to the nanoparticle, wherein the carbon nanoparticle is spherical and has a diameter of about 30 nm to about 70 nm, and wherein the carbon nanoparticle comprises iron, wherein the iron concentration of the nanoparticle is from 0.5% to 2.0%; wherein the antigenic protein or…
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- What does patent US9107858B2 cover?
- The present invention provides compositions and methods for targeting dendritic cells of the immune system. In particular, the compositions comprise carbon nanoparticles, optionally magnetic carbon nanoparticles comprising iron, which are preferentially endocytosed by dendritic cells compared to macrophages when contacted with a biological sample. The nanoparticles of the present invention may …
- Who is the assignee on this patent?
- Denes Ferencz S, Fabry Zsuzsanna, Sandor Matyas, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification A61K39/00. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Aug 18 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).