Biomimetic vascular network and devices using the same
US-9498320-B2 · Nov 22, 2016 · US
Small diameter vascular graft produced by a hybrid method
US9107739B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9107739-B2 |
| Application number | US-201013511511-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 24, 2010 |
| Priority date | Nov 25, 2009 |
| Publication date | Aug 18, 2015 |
| Grant date | Aug 18, 2015 |
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Abstract
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The present invention relates to a hybrid graft and methods of generating the hybrid graft. The hybrid graft comprises an exterior surface and a luminal surface. The luminal surface comprises a micropattern of grooves to which cells adhere and orient along. The exterior surface comprises electrospun microfibers wherein the microfibers provide mechanical properties to the graft. The hybrid graft is capable supporting endothelial cell attachment, endothelial cell alignment, cell proliferation, and maintaining their in vivo function. The graft of the invention can recapitulate the in vivo morphology and function of natural vascular endothelium.
First claim
Opening claim text (preview).
The invention claimed is: 1. A hybrid graft comprising an exterior surface and a luminal surface, wherein the luminal surface comprises a first polymer with a micropattern of grooves to which cells adhere and orient along, and wherein the exterior surface comprises a second polymer electrospun on the first polymer, wherein the second polymer provides mechanical properties to the first polymer, wherein each groove has a depth of about 1 μm, a width of about 5 μm and is positioned 5…
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- A61F2/062Primary
Human Necessities · mapped topic
Human Necessities · mapped topic
Textiles & Paper · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
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Frequently asked questions
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- What does patent US9107739B2 cover?
- The present invention relates to a hybrid graft and methods of generating the hybrid graft. The hybrid graft comprises an exterior surface and a luminal surface. The luminal surface comprises a micropattern of grooves to which cells adhere and orient along. The exterior surface comprises electrospun microfibers wherein the microfibers provide mechanical properties to the graft. The hybrid graft…
- Who is the assignee on this patent?
- Lelkes Peter I, Li Mengyan, Perets Anat, and 6 more
- What technology area does this patent fall under?
- Primary CPC classification A61F2/062. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Aug 18 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).