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Sequence-specific extraction and analysis of DNA-bound proteins
US9103827B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9103827-B2 |
| Application number | US-201113884716-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 10, 2011 |
| Priority date | Nov 10, 2010 |
| Publication date | Aug 11, 2015 |
| Grant date | Aug 11, 2015 |
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Abstract
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An automated protein preparation technology that may use magnetic microparticles to isolate proteins in their native state from specific genomic loci of interest via the chromatin to which they are bound is described. After extraction, the targeted proteins may be purified for downstream analysis by quantitative mass spectrometry or ELISA. The identification of DNA-bound proteins, histones and their post-translational modification is of high scientific and pharmaceutical importance due to the role of DNA-binding proteins in the cauzation and development of human disease; in particular, cancer.
First claim
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What is claimed is: 1. A method of isolating a nucleic acid binding protein comprising: providing a sample that may contain a first nucleic acid having a nucleic acid binding protein bound thereon; providing a second nucleic acid that has an affinity label and is capable of binding to the first nucleic acid to form a complex; isolating the complex through binding of the affinity label to a moiety capable of binding the affinity label; and obtaining the nucleic acid binding p…
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- G01N33/566Primary
Physics · mapped topic
- G01N33/6842Primary
Physics · mapped topic
Physics · mapped topic
Physics · mapped topic
Physics · mapped topic
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- What does patent US9103827B2 cover?
- An automated protein preparation technology that may use magnetic microparticles to isolate proteins in their native state from specific genomic loci of interest via the chromatin to which they are bound is described. After extraction, the targeted proteins may be purified for downstream analysis by quantitative mass spectrometry or ELISA. The identification of DNA-bound proteins, histones and …
- Who is the assignee on this patent?
- Dapprich Johannes, Garcia Benjamin, Leroy Gary, and 2 more
- What technology area does this patent fall under?
- Primary CPC classification G01N33/566. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Aug 11 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).