Method for the determination of botulinum neurotoxin biological activity
US-9212355-B2 · Dec 15, 2015 · US
Method for screening toxin neutralizing peptide, STX2 inhibiting peptide and verotoxin neutralizing agent
US9103820B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9103820-B2 |
| Application number | US-63100805-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 28, 2005 |
| Priority date | Jun 28, 2004 |
| Publication date | Aug 11, 2015 |
| Grant date | Aug 11, 2015 |
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Abstract
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A screening method directed towards; (1) specifying a receptor binding site by introduction of mutation, and (2) specifying a binding site-specific peptide motif on the basis of an amino acid selection ratio by contrast between a peptide motif bound to a wild-type subunit and a peptide motif bound to a mutant functionally deficient in the binding site according to a peptide library method. A peptide which inhibits a toxin whose receptor binding portion has a subunit structure is screened. Accordingly, an STX2 inhibitor in which an STX2 inhibiting peptide is incorporated in a molecular nuclear structure portion having three molecules of lysine (Lys) peptide-linked thereto and which is easy to synthesize and can inhibit verotoxin is provided.
First claim
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The invention claimed is: 1. A method for screening for a tetravalent peptide which can neutralize a Shiga Toxin 2 toxin, the method comprising: (a) providing a wild-type Shiga Toxin 2 (STX2) toxin comprising a plurality of subunits and having a receptor-binding site; (b) providing a mutant of said wild type STX2 toxin having a mutation in the receptor-binding site which decreases the affinity of the mutant for a receptor of the toxin as compared to the affinity of the wild type…
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- What does patent US9103820B2 cover?
- A screening method directed towards; (1) specifying a receptor binding site by introduction of mutation, and (2) specifying a binding site-specific peptide motif on the basis of an amino acid selection ratio by contrast between a peptide motif bound to a wild-type subunit and a peptide motif bound to a mutant functionally deficient in the binding site according to a peptide library method. A pe…
- Who is the assignee on this patent?
- Nishikawa Kiyotaka, Japan Science & Tech Agency
- What technology area does this patent fall under?
- Primary CPC classification G01N33/5014. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Aug 11 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).