Microparticle analysis apparatus and microparticle analysis system
US-2015377763-A1 · Dec 31, 2015 · US
Determination of isoelectric points of biomolecules using capacitive sensors
US9103770B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9103770-B2 |
| Application number | US-201313971454-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 20, 2013 |
| Priority date | Nov 15, 2012 |
| Publication date | Aug 11, 2015 |
| Grant date | Aug 11, 2015 |
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Abstract
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A mechanism is provided for determining an isoelectric point of a molecule. A first group of capacitance versus voltage curves of a capacitor is measured. The capacitor includes a substrate, dielectric layer, and conductive solution. The first group of curves is measured for pH values of the solution without the molecule bound to a functionalized material on the dielectric layer of the capacitor. A second group of capacitance versus voltage curves of the capacitor is measured when the molecule is present in the solution, where the molecule is bound to the functionalized material of the dielectric layer of the capacitor. A shift is determined in the second group of curves from the first group of curves at each pH value. The isoelectric point of the molecule is determined by extrapolating a pH value corresponding to a shift voltage being zero, when the shift is compared to the pH values.
First claim
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What is claimed is: 1. A method of determining an isoelectric point of a target molecule, the method comprising: measuring a first plurality of capacitance versus voltage curves of a capacitor, the capacitor comprising a substrate, a dielectric layer, and an electrically conductive solution; wherein the first plurality of capacitance versus voltage curves are measured for a plurality of pH values of the electrically conductive solution without the target molecule being bound to…
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Physics · mapped topic
Physics · mapped topic
Physics · mapped topic
Physics · mapped topic
- G01N27/221Primary
Physics · mapped topic
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- What does patent US9103770B2 cover?
- A mechanism is provided for determining an isoelectric point of a molecule. A first group of capacitance versus voltage curves of a capacitor is measured. The capacitor includes a substrate, dielectric layer, and conductive solution. The first group of curves is measured for pH values of the solution without the molecule bound to a functionalized material on the dielectric layer of the capacito…
- Who is the assignee on this patent?
- IBM
- What technology area does this patent fall under?
- Primary CPC classification G01N27/221. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Aug 11 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).