Compositions and methods for targeted delivery to cells
US-2024390271-A1 · Nov 28, 2024 · US
Genetic inhibition by double-stranded RNA
US9102939B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9102939-B2 |
| Application number | US-201213647177-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 8, 2012 |
| Priority date | Dec 23, 1997 |
| Publication date | Aug 11, 2015 |
| Grant date | Aug 11, 2015 |
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Abstract
Official abstract text for this publication.
A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.
First claim
Opening claim text (preview).
We claim: 1. A method to inhibit expression of a target gene in an animal cell comprising introduction of a ribonucleic acid (RNA) into the cell in an amount sufficient to inhibit expression of the target gene, wherein the RNA comprises a double-stranded structure with an identical nucleotide sequence as compared to a portion of the target gene. 2. The method of claim 1 in which the target gene is a cellular gene. 3. The method of claim 1…
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Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
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- What does patent US9102939B2 cover?
- A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is d…
- Who is the assignee on this patent?
- Carnegie Inst Of Washington, Univ Massachusetts, Carnegie Inst Of Washington
- What technology area does this patent fall under?
- Primary CPC classification A61K31/7105. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Aug 11 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).