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US-9301968-B2 · Apr 5, 2016 · US
2′ and 5′ modified monomers and oligonucleotides
US9102938B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9102938-B2 |
| Application number | US-201113638891-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 31, 2011 |
| Priority date | Apr 1, 2010 |
| Publication date | Aug 11, 2015 |
| Grant date | Aug 11, 2015 |
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Abstract
Official abstract text for this publication.
The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least on nucleoside of formula (2):Formula (1) and Formula (2). Another aspect of the invention relates to a method of inhibiting the expression of a gene in call, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.
First claim
Opening claim text (preview).
The invention claimed is: 1. A nucleoside of formula (3): or isomers thereof, wherein: one of D 1 and D 2 is H, or a protecting group and the other of D 1 and D 2 is H, a protecting group or a reactive phosphorus group; T 1 and T 2 are each independently selected from the group consisting of H, C 1 -C 9 alkyl, C 2 -C 9 alkenyl, C 2 -C 9 alkynyl, substituted C…
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Classifications
- C07H19/067Primary
Chemistry & Metallurgy · mapped topic
- C12N15/113Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
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- What does patent US9102938B2 cover?
- The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least on nucleoside of formula (2):Formula (1) and Formula (2). Another aspect of the invention relates to a method of inhibiting the expression of a gene in call, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a tim…
- Who is the assignee on this patent?
- Rajeev Kallanthottathil G, Manoharan Muthiah, Swayze Eric E, and 2 more
- What technology area does this patent fall under?
- Primary CPC classification C07H19/067. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Aug 11 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).