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US-2024132925-A1 · Apr 25, 2024 · US
Orthogonal translation components for the in vivo incorporation of unnatural amino acids
US9102932B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9102932-B2 |
| Application number | US-201213492296-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 8, 2012 |
| Priority date | Oct 27, 2004 |
| Publication date | Aug 11, 2015 |
| Grant date | Aug 11, 2015 |
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Abstract
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The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetase that can incorporate unnatural amino acid into proteins produced in eubacterial host cells such as E. coli , or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing unnatural amino acids, and translation systems.
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What is claimed is: 1. A translation system comprising: (a) a first unnatural amino acid which is p-(2 amino-1-hydroxyethyl)-L-phenylalanine; (b) a first orthogonal aminoacyl-tRNA synthetase (O-RS); and (c) a first orthogonal tRNA (O-tRNA); wherein said first O-RS preferentially aminoacylates said first O-tRNA with said first unnatural amino acid; and wherein the first O-RS comprises at least 90% identity to the amino acid sequence of SEQ ID NO 59. 2.…
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- What does patent US9102932B2 cover?
- The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetase that can incorporate unnatural amino acid into proteins produced in eubacterial host cells such as E. coli , or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for prod…
- Who is the assignee on this patent?
- Schultz Peter G, Alfonta Lital, Chittuluru Johnathan R, and 11 more
- What technology area does this patent fall under?
- Primary CPC classification C12N9/93. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Aug 11 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).