Microorganisms genetically engineered to have modified N-glycosylation activity
US-9222083-B2 · Dec 29, 2015 · US
Trehalose phosphorylases and their use in the biocatalytic production of trehalose-analogues and glycosyl phosphates
US9102922B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9102922-B2 |
| Application number | US-201113885789-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 9, 2011 |
| Priority date | Dec 14, 2010 |
| Publication date | Aug 11, 2015 |
| Grant date | Aug 11, 2015 |
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Abstract
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The present invention relates to trehalose phosphorylases which are useful for the industrial production of trehalose-analogs and glycosyl phosphates. More specifically, the invention discloses trehalose phosphorylases which are mutated in specific amino acid regions. These specific mutations result in modified substrate specificities of the enzymes. In addition, the present invention discloses a wild type trehalose phosphorylase from the marine organism Caldanaerobacter subterraneus , and mutated types thereof, which are highly thermostable and have a broad acceptor and donor specificity.
First claim
Opening claim text (preview).
The invention claimed is: 1. A mutated trehalose phosphorylase comprising the amino acid sequence of SEQ ID NO: 1, except for a mutation in one or more of amino acid positions 371, 442, 450, 649, 659, or 693, and wherein said mutated trehalose phosphorylase has an increased catalytic efficiency towards its acceptor or donor substrate compared to the corresponding wild-type trehalose phosphorylase. 2. The mutated trehalose phosphorylase of claim 1 , wherein said…
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Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
- C12N9/1051Primary
Chemistry & Metallurgy · mapped topic
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- What does patent US9102922B2 cover?
- The present invention relates to trehalose phosphorylases which are useful for the industrial production of trehalose-analogs and glycosyl phosphates. More specifically, the invention discloses trehalose phosphorylases which are mutated in specific amino acid regions. These specific mutations result in modified substrate specificities of the enzymes. In addition, the present invention discloses…
- Who is the assignee on this patent?
- Van Der Borght Jef, Desmet Tom, Soetaert Wim, and 2 more
- What technology area does this patent fall under?
- Primary CPC classification C12N9/1051. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Aug 11 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).