Amidoimidazopyridazines as mknk-1 kinase inhibitors
US-2015376189-A1 · Dec 31, 2015 · US
US9102683B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9102683-B2 |
| Application number | US-201213598130-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 29, 2012 |
| Priority date | Aug 29, 2011 |
| Publication date | Aug 11, 2015 |
| Grant date | Aug 11, 2015 |
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Described herein are methods for synthesizing heterocyclic, 8-membered ring structures. The methods may allow for preparation of highly substituted 8-membered rings. Also disclosed are heterocyclic, 8-membered ring compounds and pharmaceutical compositions comprising the compounds.
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The invention claimed is: 1. A method of synthesizing a compound of formula (I): wherein: X is selected from the group consisting of O and NR 1 ; R 1 is selected from the group consisting of hydrogen, alkyl, and a nitrogen protecting group; R 2 is selected from the group consisting of —C(O)O—, —C(O)—, —O—, —NR 4 — and —CR 5 2 —; each…
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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