Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c
US-2015368246-A1 · Dec 24, 2015 · US
US9102676B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9102676-B2 |
| Application number | US-201414297167-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 5, 2014 |
| Priority date | Dec 14, 2009 |
| Publication date | Aug 11, 2015 |
| Grant date | Aug 11, 2015 |
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The present invention relates to compounds of general Formula (I) or a pharmaceutically acceptable salt thereof. The compounds can be used in the treatment of immune, autoimmune, inflammatory diseases, cardiovascular diseases, infectious diseases, bone resorption disorders, neurodegenerative diseases or proliferative diseases.
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The invention claimed is: 1. A method of inhibiting MK2 activity comprising the step of contacting a cell with a compound selected from the group consisting of: 2′-(2-(benzofuran-2-yl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1H)-one; 2′-(2′-amino-2,5′-bipyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4′(1′H)-one; 2′-(2-(5-methoxypyridin-3-yl)pyrimidin-4-yl)-5′,6′-dihydrospiro[piperidine-4,7′-pyrrolo[3,2-c]pyridin]-4…
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