Heterocyclic modulators of lipid synthesis
US-2024400552-A1 · Dec 5, 2024 · US
US9102675B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9102675-B2 |
| Application number | US-201214359705-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 30, 2012 |
| Priority date | Nov 22, 2011 |
| Publication date | Aug 11, 2015 |
| Grant date | Aug 11, 2015 |
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Compounds of the formula (I) in which R 1 , R 2 , X and Y have the meanings indicated in claim 1 , are inhibitors of TBK1 and IKKε and can be employed, inter alia, for the treatment of cancer and inflammatory diseases.
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The invention claimed is: 1. A compound of formula I in which X denotes CH or N, R 1 denotes H, A or Cyc, R 2 denotes O[C(R 6 ) 2 ] n Het 1 or O[C(R 6 ) 2 ] n Cyc, R 3 denotes O[C(R 6 ) 2 ] n Het 2 , Ar or Het 2 , R 4 denotes H or OR 6 , R 5 denotes H or OR 6 , R 6 denotes H or methyl, Het 1 denotes dihydropyrrolyl, pyrrolidinyl, azetidinyl, oxetany…
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