Substituted pyrrolo[3,2-c]pyridines as TrkA kinase inhibitors

Patent metadata

Field	Value
Publication number	US-9102673-B2
Application number	US-201214131861-A
Country	US
Kind code	B2
Filing date	Jul 6, 2012
Priority date	Jul 12, 2011
Publication date	Aug 11, 2015
Grant date	Aug 11, 2015

Abstract

The present invention is directed to compounds of formula I and Ia: which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.

First claim

What is claimed is:

1. A compound of formula I:

or a pharmaceutically acceptable salt thereof, wherein
————— is a bond that when present forms a double bond with bond a or bond b;
X 1 is —N or —N + —O − ;
X 2 is —CH;
X 3 is —N;
Y is —CH;
——— is present at a;
R is a C 6-10 aryl, C 5-10 heteroaryl, said aryl…

Assignees

• Hanney Barbara
• Manley Peter
• Rudd Michael T
• Sanders John M
• Stachel Shawn J
• Henze Darrell
• Merck Sharp & Dohme

Inventors

• Hanney Barbara
• Manley Peter
• Rudd Michael T
• Sanders John M
• Stachel Shawn J
• Henze Darrell

Classifications

• A61P35/00

  Human Necessities · mapped topic

• C07D403/04

  Chemistry & Metallurgy · mapped topic

• C07D405/04

  Chemistry & Metallurgy · mapped topic

• C07D487/04

  Chemistry & Metallurgy · mapped topic

• C07D471/04 Primary

  Chemistry & Metallurgy · mapped topic