Asgpr-binding compounds for the degradation of extracellular proteins
US-2024424108-A1 · Dec 26, 2024 · US
US9102660B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9102660-B2 |
| Application number | US-201414223034-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 24, 2014 |
| Priority date | Mar 25, 2013 |
| Publication date | Aug 11, 2015 |
| Grant date | Aug 11, 2015 |
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A process provides for producing chiral prostacyclin derivatives of Formula (I) in high yield from meso anhydrides.
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What is claimed is: 1. A process for the preparation of a compound of Formula I, or a pharmaceutically acceptable salt thereof: the process comprising: coupling a meso anhydride of Formula III with an ester compound of Formula IV in the presence of a chiral ligand, to provide a compound of Formula V:…
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