P2x3 and/or p2x2/3 receptor antagonist, pharmaceutical composition comprising same, and use thereof
US-2024400592-A1 · Dec 5, 2024 · US
US9102657B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9102657-B2 |
| Application number | US-201214359734-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 22, 2012 |
| Priority date | Nov 25, 2011 |
| Publication date | Aug 11, 2015 |
| Grant date | Aug 11, 2015 |
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The invention relates to a sodium salt of (R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid, and to a sodium salt of (R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid which is in a crystalline form or in at least partially crystalline form, as well as a process for the preparation of the same, methods of using such salt to treat subjects suffering from conditions which can be ameliorated by the administration of an inhibitor of the enzyme TAFIa (activated thrombin-activatable fibrinolysis inhibitor).
Opening claim text (preview).
The invention claimed is: 1. A Sodium salt of (R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid as a dihydrate of the structure: 2. The Sodium salt according to claim 1 wherein the crystalline salt exhibits in an X-ray powder diffraction pattern measured in transmission with CuKα 1 radiation at room temperature a characteristic r…
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