Flap modulators
US-2015376212-A1 · Dec 31, 2015 · US
US9102639B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9102639-B2 |
| Application number | US-201314099276-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 6, 2013 |
| Priority date | Oct 19, 2004 |
| Publication date | Aug 11, 2015 |
| Grant date | Aug 11, 2015 |
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This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
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What is claimed is: 1. A compound of the Formula: and solvates, resolved enantiomers, diastereomers, racemic mixtures and pharmaceutically acceptable salts thereof, wherein: X is S, R is Z—NR 2 R 3 , Z—OH, or Z—OP(═O)(OR a )(OR a ); R 1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, saturated or partially unsaturated cycloalkyl, saturated or partia…
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