Prodrugs of NH-acidic compounds

Patent metadata

Field	Value
Publication number	US-9102618-B2
Application number	US-201414172391-A
Country	US
Kind code	B2
Filing date	Feb 4, 2014
Priority date	Jun 25, 2009
Publication date	Aug 11, 2015
Grant date	Aug 11, 2015

Abstract

The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a patient an effective amount of a prodrug compound of the invention wherein upon administration to the patient, release of the parent drug from the prodrug is sustained release. Prodrug compounds suitable for use in the methods of the invention are labile conjugates of parent drugs that are derivatized through carbonyl linked prodrug moieties. The prodrug compounds of the invention can be used to treat any condition for which the lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug is useful as a treatment.

First claim

What is claimed is:

1. A compound of having the formula:

wherein
represents a single or double bond;
R 1 is selected from —C(R A )(R B )—OC(O)OR 20 , —C(R A )(R B )—OC(O)R 20 , —C(R A )(R B )—OC(O)NR 20 R 21 ;
Each R A and R B independently selected from hydrogen, halogen, aliphatic, substituted aliphatic, aryl or substituted aryl;
Each R 20 and R 21 is inde…

Assignees

• Alkermes Pharma Ireland Ltd

Inventors

• Blumberg Laura Cook
• Remenar Julius F
• Almarsson Orn
• Zeidan Tarek A

Classifications

• A61P3/10

  Human Necessities · mapped topic

• A61P43/00

  Human Necessities · mapped topic

• A61P25/00

  Human Necessities · mapped topic

• A61P25/22

  Human Necessities · mapped topic

• A61K31/554

  Human Necessities · mapped topic