Hydrogels comprising cell adhesive peptides and methods of use thereof
US-2024376438-A1 · Nov 14, 2024 · US
Cell-independent fabrication of tissue equivalents
US9101693B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9101693-B2 |
| Application number | US-63128805-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 5, 2005 |
| Priority date | Jul 5, 2004 |
| Publication date | Aug 11, 2015 |
| Grant date | Aug 11, 2015 |
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Abstract
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This invention relates to cell-independent processes which mimic cellular bioremodelling and produce organized biomaterials which have mechanical properties and viable cell densities suitable for use as functional tissue implants. The biomaterials are produced by providing a gel comprising a matrix of scaffold fibers of and an interstitial fluid; and plastically compacting the gel to produce the biomaterial. The biomaterials may comprise 3D structures such as layering, alignment and meso-scale zonal heterogeneities of cells and matrix which mimic native tissue structure. Biomaterials with biomimetic structure as described herein may be useful in a range of therapeutic applications.
First claim
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The invention claimed is: 1. A method of producing a biomaterial comprising viable mammalian cells, wherein the method comprises: providing a gel comprising a matrix of fibers and a liquid, said liquid being interstitial to the matrix of fibers, and the interstitial liquid containing viable mammalian cells, wherein said gel is produced by polymerisation of monomers dissolved in liquid containing viable mammalian cells; and, applying an external compaction to the gel to expel 50%…
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- What does patent US9101693B2 cover?
- This invention relates to cell-independent processes which mimic cellular bioremodelling and produce organized biomaterials which have mechanical properties and viable cell densities suitable for use as functional tissue implants. The biomaterials are produced by providing a gel comprising a matrix of scaffold fibers of and an interstitial fluid; and plastically compacting the gel to produce th…
- Who is the assignee on this patent?
- Brown Robert, Nazhat Showan, Mudera Vivek, and 2 more
- What technology area does this patent fall under?
- Primary CPC classification A61L27/52. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Aug 11 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).