Hyperpolarized esters as metabolic markers in mr
US-2015374854-A1 · Dec 31, 2015 · US
US9101673B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9101673-B2 |
| Application number | US-47952009-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 5, 2009 |
| Priority date | May 30, 2007 |
| Publication date | Aug 11, 2015 |
| Grant date | Aug 11, 2015 |
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The present invention is directed toward novel fluorine-18 labeled rhodamine dye derivatives and methods of making the same. The present invention is also directed toward methods of using novel fluorine-18 labeled rhodamine dye derivatives as positron emission tomography imaging agents and myocardial perfusion imaging agents.
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What is claimed: 1. A compound comprising an 18 F labeled rhodamine derivative according to formula I: wherein R 2 and R 3 are alkyl; R 1 , R 4 , R 5 , R 6 , R 7 , R 8 , and R 9 are hydrogen; A 1 is carbon or nitrogen, if A 1 is nitrogen, then R 6 is absent; R 15 is CH 2 CH 2 OCH 2 CH 2 18 F; and A − is…
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