Compositions and medical devices for controlled release of nitric oxide and methods of production thereof
US-9216198-B2 · Dec 22, 2015 · US
US9101672B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9101672-B2 |
| Application number | US-201113218625-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 26, 2011 |
| Priority date | Aug 26, 2011 |
| Publication date | Aug 11, 2015 |
| Grant date | Aug 11, 2015 |
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Disclosed herein is the novel use of a gold nanocluser for ameliorating oxidative stress and/or aging of a cultured cell or a subject having an oxidative stress and/or aging condition mediated by a vascular factor. The gold nanocluster has a particle size ranging from about 0.1 to 20 nm, and preferably is dihydrolipoic acid (DHLA) coated gold nanocluster.
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What is claimed is: 1. A method of ameliorating oxidative stress and/or aging of a cultured cell comprising contacting the cultured cell with about 1 to 1,000 nM of a dihydrolipoic acid (DHLA) coated gold nanocluster having a particle size ranging from about 0.1 to 20 nm, wherein, the DHLA coated gold nanocluster consists of a gold nanocluster formed by a plurality of gold nanoparticles, and a plurality of DHLAs coated on the gold nanocluster; and the cultured cell is selected f…
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