Biodegradable poly(beta-amino esters) and uses thereof

Patent metadata

Field	Value
Publication number	US-9101666-B2
Application number	US-201314029552-A
Country	US
Kind code	B2
Filing date	Sep 17, 2013
Priority date	Oct 10, 2000
Publication date	Aug 11, 2015
Grant date	Aug 11, 2015

Abstract

Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

First claim

What is claimed is:

1. A polymer of formula:

or salt thereof;
wherein:
linker B is selected from the group consisting of carbon chains, heteroatom-containing carbon chains, and carbon chains and heteroatom-containing carbon chains with at least one substituent selected from the group consisting of branched and unbranched alkyl, branched and unbranched alkenyl, branch…

Assignees

• Massachusetts Inst Technology

Inventors

• Langer Robert S
• Lynn David M
• Putnam David A
• Amiji Mansoor M
• Anderson Daniel Griffith

Classifications

• A61K47/6929

  Human Necessities · mapped topic

• C08G73/0273

  Chemistry & Metallurgy · mapped topic

• A61K47/593

  Human Necessities · mapped topic

• A61K47/59

  Human Necessities · mapped topic

• A61P31/04

  Human Necessities · mapped topic