Compositions and methods for viral sensitization
US-2024360115-A1 · Oct 31, 2024 · US
US9101653B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9101653-B2 |
| Application number | US-201213594611-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 24, 2012 |
| Priority date | Aug 26, 2011 |
| Publication date | Aug 11, 2015 |
| Grant date | Aug 11, 2015 |
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The invention provides a recombinant biologically contained influenza virus that is a PB2 knockout virus, e.g., one that is useful to generate a multivalent vaccine, and methods of making and using that virus.
Opening claim text (preview).
What is claimed is: 1. A vaccine comprising an effective amount of an isolated stable, biologically contained multivalent influenza virus comprising: i) 8 different gene segments including a PA viral gene segment, a PB1 viral gene segment, a mutant PB2 viral gene segment, a HA viral gene segment, a NA viral gene segment, a NP viral gene segment, a M (M1 and M2) viral gene segment, and a NS (NS1 and NS2) viral gene segment, ii) 8 different gene segments including a PA viral gene seg…
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