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Lipid formulated compositions and methods for inhibiting expression of transthyretin (TTR)
US9101643B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9101643-B2 |
| Application number | US-201013503843-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 3, 2010 |
| Priority date | Nov 3, 2009 |
| Publication date | Aug 11, 2015 |
| Grant date | Aug 11, 2015 |
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Abstract
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The invention relates to lipid formulated double-stranded ribonucleic acid (dsRNA) targeting a transthyretin (TTR) gene, and methods of using the dsRNA to inhibit expression of TTR.
First claim
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I claim: 1. A method for reducing a TTR amyloid deposit by >90% in a subject having the TTR amyloid deposit, comprising administering to the subject an effective amount of a composition comprising a TTR dsRNA and determining TTR amyloid deposition in the subject, wherein: the TTR dsRNA comprises a sense strand and an antisense strand, the antisense strand consisting of SEQ ID NO:1010 and the sense strand consisting of SEQ ID NO:1009; the effective amount is 0.01-30 mg/kg TTR dsRNA;…
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Frequently asked questions
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- What does patent US9101643B2 cover?
- The invention relates to lipid formulated double-stranded ribonucleic acid (dsRNA) targeting a transthyretin (TTR) gene, and methods of using the dsRNA to inhibit expression of TTR.
- Who is the assignee on this patent?
- Sah Dinah Wen-Yee, Alnylam Pharmaceuticals Inc
- What technology area does this patent fall under?
- Primary CPC classification A61K31/7088. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Aug 11 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).