Substituted nucleosides, nucleotides and analogs thereof
US-2015366887-A1 · Dec 24, 2015 · US
US9101641B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9101641-B2 |
| Application number | US-201314091073-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 26, 2013 |
| Priority date | Mar 29, 2004 |
| Publication date | Aug 11, 2015 |
| Grant date | Aug 11, 2015 |
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This application relates to combination therapies including triciribine and related compounds and taxanes and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.
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What is claimed is: 1. A method for treating a subject having a tumor or cancer, which tumor or cancer overexpresses AKT kinase comprising: (i) determining whether the subject has a tumor or cancer that overexpresses AKT kinase; (ii) if said subject has a tumor or cancer that overexpresses AKT kinase, a. administering to said subject: i. 45 mg/m 2 or less of at least one compound of formula I selected from the group consisting of the following compounds:…
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