Griseofulvin compound and pharmaceutical use thereof
US-11993593-B2 · May 28, 2024 · US
US9101601B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9101601-B2 |
| Application number | US-201314370140-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 3, 2013 |
| Priority date | Jan 9, 2012 |
| Publication date | Aug 11, 2015 |
| Grant date | Aug 11, 2015 |
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Disclosed are methods of treating an animal for insulin resistance and associated diseases or conditions, activating the transcriptional activity of heat shock factor 1 (HSF1), or inducing the expression of heat shock protein 70 (HSP70) in an animal in need thereof, wherein the methods involve administering an effective amount of one or more compounds of formula (I) or an epimer thereof, wherein Ar, and R 1 -R 6 are described herein. Examples of diseases or conditions associated with insulin resistance include diabetes, obesity, inflammation, metabolic syndrome, polycystic ovary disease, arteriosclerosis, non-alcoholic fatty liver disease, reproductive abnormality in a female, and growth abnormality.
Opening claim text (preview).
The invention claimed is: 1. A method of treating an animal for insulin resistance or type II diabetes comprising administering to the animal an effective amount of a compound of formula (I): or an epimer thereof; wherein Ar is an aryl group, optionally substituted with one or more substituents selected from the group consisting of C 1 -C 6 alkyl, C 1 -C 6 hydroxyalkyl…
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
Human Necessities · mapped topic
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