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Suppression of cancer growth and metastasis using nordihydroguaiaretic acid derivatives with 7-hydroxystaurosporine
US9101567B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9101567-B2 |
| Application number | US-201113579953-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 22, 2011 |
| Priority date | Feb 22, 2010 |
| Publication date | Aug 11, 2015 |
| Grant date | Aug 11, 2015 |
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Abstract
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Disclosed is a composition comprising a derivative of NDGA and 7-hydroxystaurosporine. The composition can be in a unit dose form or kit. Also disclosed are methods for achieving cytotoxicity, particularly of rapidly dividing cells such as cancer, by administering a composition of the invention. In various embodiments of the invention subjects with cancer achieve prolonged survival and/or diminution in the size of their malignancies and cancer metastasis.
First claim
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We claim: 1. A synergistic antineoplastic composition comprising about 20 μM to about 80 μM of a compound selected from the group consisting of tetra-o-methyl nordihydroguaiaretic acid (M 4 N) and maltose-M 3 N; and about 1 μM to about 10 μM of 7-hydroxystaurosporine. 2. A method of inhibiting tumor growth in an animal, said method comprising administering the synergistic antineoplastic composition of claim 1 . 3. The method of claim 2…
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Human Necessities · mapped topic
Human Necessities · mapped topic
- A61K31/09Primary
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
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- What does patent US9101567B2 cover?
- Disclosed is a composition comprising a derivative of NDGA and 7-hydroxystaurosporine. The composition can be in a unit dose form or kit. Also disclosed are methods for achieving cytotoxicity, particularly of rapidly dividing cells such as cancer, by administering a composition of the invention. In various embodiments of the invention subjects with cancer achieve prolonged survival and/or dimin…
- Who is the assignee on this patent?
- Huang Ru Chih C, Kimura Kotohiko, Univ Johns Hopkins
- What technology area does this patent fall under?
- Primary CPC classification A61K31/09. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Aug 11 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).