Selective removal of a protein from a mixture of proteins using activated carbon by adjusting solution conditions
US-2015376232-A1 · Dec 31, 2015 · US
Rapid isolation of monoclonal antibodies from animals
US9090674B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9090674-B2 |
| Application number | US-201113109467-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 17, 2011 |
| Priority date | May 17, 2010 |
| Publication date | Jul 28, 2015 |
| Grant date | Jul 28, 2015 |
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Abstract
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Methods and compositions for identification of candidate antigen-specific variable regions as well as generation of antibodies or antigen-binding fragments that could have desired antigen specificity are provided. For example, in certain aspects methods for determining amino acid sequences of serum antibody CDR and abundancy level are described. In some aspects, methods for determining nucleic acid sequences of antibody variable region sequences and frequency are provided. Furthermore, the invention provides methods for identification and generation of antibody or antigen-binding fragments that comprise highly-represented CDR.
First claim
Opening claim text (preview).
What is claimed is: 1. A method for determining antibody sequences in circulation from a subject, wherein the subject has a tumor, an infectious disease, an autoimmune disease, has been immunized or has been exposed to an antigen which is an infectious agent, a tumor antigen, a tumor cell or a self-antigen, comprising: a) obtaining mature B cells from the subject; b) isolating nucleic acids encoding VH and VL gene repertoires encoded by the mature B cells of the subject, and seq…
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Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
- C07K16/065Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US9090674B2 cover?
- Methods and compositions for identification of candidate antigen-specific variable regions as well as generation of antibodies or antigen-binding fragments that could have desired antigen specificity are provided. For example, in certain aspects methods for determining amino acid sequences of serum antibody CDR and abundancy level are described. In some aspects, methods for determining nucleic …
- Who is the assignee on this patent?
- Reddy Sai, Ge Xin, Lavinder Jason, and 5 more
- What technology area does this patent fall under?
- Primary CPC classification C07K16/065. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jul 28 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).