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US-12013404-B2 · Jun 18, 2024 · US
High throughput screening of ion channels
US9080959B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9080959-B2 |
| Application number | US-201213662190-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 26, 2012 |
| Priority date | Apr 9, 2010 |
| Publication date | Jul 14, 2015 |
| Grant date | Jul 14, 2015 |
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Abstract
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Multi-well plates having contoured well designs allow multi-stage high throughput parallel assaying of ion channels or ion transporters. A well of a multi-well plate has a bottom region that is sized and shaped to simultaneous accommodate a sensing electrode and a pipette for delivering, e.g., test compounds, wash fluid, and optionally ligands. Such multi-well plates may be coupled with an instrument having a pipette head and an electrode plate. Such arrangement facilitates fluidic contact between cells and fluids provided via a pipette. It also facilitates washing of wells with buffers or other wash solutions to allow serial exposure of test cells to various reagents or other stimuli. Generally, the design allows control and test experiments to be performed on the same cell (or cells) in a single well.
First claim
Opening claim text (preview).
What is claimed is: 1. A multi-well plate comprising: a plurality of wells, each with a top portion and a bottom portion, wherein at least one well of the multi-well plate has an internal member positioned between the top and bottom portions and the bottom portion of the at least one well comprises: (a) a cell cavity formed from its top by a horizontal portion of the internal member and being opened at a through hole within the horizontal portion towards the top portion of…
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Classifications
- G01N27/327Primary
Physics · mapped topic
- B01L3/5085Primary
Operations & Transport · mapped topic
Operations & Transport · mapped topic
Physics · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US9080959B2 cover?
- Multi-well plates having contoured well designs allow multi-stage high throughput parallel assaying of ion channels or ion transporters. A well of a multi-well plate has a bottom region that is sized and shaped to simultaneous accommodate a sensing electrode and a pipette for delivering, e.g., test compounds, wash fluid, and optionally ligands. Such multi-well plates may be coupled with an inst…
- Who is the assignee on this patent?
- Molecular Devices Llc, Molecula Devices Llc
- What technology area does this patent fall under?
- Primary CPC classification G01N27/327. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Jul 14 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).