Calibration of analytical instrument
US-2024393301-A1 · Nov 28, 2024 · US
Methods of validating candidate compounds for use in treating COPD and other diseases
US9068942B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9068942-B2 |
| Application number | US-201313836332-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 15, 2013 |
| Priority date | Jan 26, 2010 |
| Publication date | Jun 30, 2015 |
| Grant date | Jun 30, 2015 |
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Abstract
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The present invention relates to methods of diagnosing, monitoring, and treating elastin fiber injuries. In additional preferred embodiments, the present invention relates to methods of validating candidate compounds for use in treating chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema, refractory asthma, and other related diseases. Examples of such methods include determining if the candidate compound decreases the degradation of elastic fiber in a patient administered the candidate compound by measuring, using mass spectrometry employing an internal standard, a marker of elastic fiber degradation in a sample of a body fluid or a tissue of the patient. The invention provides that a decrease in the presence of the marker compared to a control validates that the candidate compound is effective to treat, prevent, or ameliorate the disease.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of validating whether a candidate compound is effective to treat, prevent, or ameliorate the effects of chronic obstructive pulmonary disease (COPD) comprising determining if the candidate compound decreases the degradation of elastin in a patient administered the candidate compound by measuring comprising an acylated pyridinoline, the amount of desmosine and isodesmosine in a sample of a body fluid or tissue of the patient, wherein a decrease in the…
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Physics · mapped topic
- G01N30/7233Primary
Physics · mapped topic
Physics · mapped topic
Cross-Sectional Technologies · mapped topic
Physics · mapped topic
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Frequently asked questions
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- What does patent US9068942B2 cover?
- The present invention relates to methods of diagnosing, monitoring, and treating elastin fiber injuries. In additional preferred embodiments, the present invention relates to methods of validating candidate compounds for use in treating chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema, refractory asthma, and other related diseases. Examples of such methods include det…
- Who is the assignee on this patent?
- Leiberman Paul, Univ Columbia, St Luke S Roosevelt Hospital Ct
- What technology area does this patent fall under?
- Primary CPC classification G01N30/7233. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Jun 30 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).