Use of compounds for inducing differentiation of mesenchymal stem cells to chondrocytes

Patent metadata

Field	Value
Publication number	US-9068166-B2
Application number	US-201113823653-A
Country	US
Kind code	B2
Filing date	Sep 16, 2011
Priority date	Sep 16, 2010
Publication date	Jun 30, 2015
Grant date	Jun 30, 2015

Abstract

Use of a compound of Formula 1 for inducing differentiation of mesenchymal stem cells to chondrocytes, and a pharmaceutical composition for treating a cartilage disease, which includes chondrocytes in which differentiation from mesenchymal stem cells is induced by the compound of Formula 1, are provided. Differentiation of the mesenchymal stem cells treated with the compound of Formula 1 to chondrocytes is specifically induced, and thus the compound can be used to effectively treat a cartilage disease such as arthritis, cartilage damage, and a cartilage defect.

First claim

The invention claimed is:

1. A method of inducing differentiation of mesenchymal stem cells to chondrocytes, comprising: incubating the mesenchymal stem cells in a medium comprising at least one compound selected from the group consisting of:
1) quinoline-8-sulfonic acid (4-hydroxy-phenyl)-amide;
2) quinoline-8-sulfonic acid (7-hydroxy-naphthalen-1-yl)-amide;
3) 2-hydroxy-5-(quinoline-8-sulfonylamino)-benzoic acid;
4) 5-(4-tert-butyl-benzenesulfonylamino)-2-hydroxy-benzoic a…

Assignees

• Hwang Ki Chul
• Jang Yang Soo
• Han Gyoon Hee
• Univ Yonsei Iacf

Inventors

• Hwang Ki Chul
• Jang Yang Soo
• Han Gyoon Hee

Classifications

• C07C311/21

  Chemistry & Metallurgy · mapped topic

• C12N5/0655 Primary

  Chemistry & Metallurgy · mapped topic

• C07C2602/10

  Chemistry & Metallurgy · mapped topic

• C07C311/17

  Chemistry & Metallurgy · mapped topic

• A61K35/32

  Human Necessities · mapped topic