Neprilysin inhibitors
US-2015376128-A1 · Dec 31, 2015 · US
Cyclic amide BACE-1 inhibitors having a benzamide substituent
US9062007B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9062007-B2 |
| Application number | US-201414148703-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 6, 2014 |
| Priority date | Aug 8, 2003 |
| Publication date | Jun 23, 2015 |
| Grant date | Jun 23, 2015 |
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- Title
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Abstract
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Disclosed are compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R 1 is R is —C(O)—N(R 27 )(R 28 ) or and the remaining variables are as defined in the specification. Also disclosed are pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of treating cognitive or neurodegenerative diseases such as Alzheimer's disease. Also disclosed are pharmaceutical compositions and methods of treating cognitive or neurodegenerative diseases comprising the compounds of formula I in combination with a β-secretase inhibitor other than those of formula I, an HMG-CoA reductase inhibitor, a gamma-secretase inhibitor, a non-steroidal anti-inflammatory agent, an N-methyl-D-aspartate receptor antagonist, a cholinesterase inhibitor or an anti-amyloid antibody.
First claim
Opening claim text (preview).
We claim: 1. A compound having the structural formula: or a pharmaceutically acceptable salt thereof, wherein: R 19 is H, alkyl, optionally substituted benzyl, benzoyl, —SO 2 alkyl; —SO 2 (optionally substituted phenyl), —SO 2 N(alkyl) 2 ; phenyl, —C(O)alkyl, —C(O)-heteroaryl, —C(O)—NH (optionally substituted phenyl), —C(O)—O-benzyl, —C(O)—CH 2 —O-alkyl, —SO 2 — (optio…
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Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
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Frequently asked questions
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- What does patent US9062007B2 cover?
- Disclosed are compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R 1 is R is —C(O)—N(R 27 )(R 28 ) or and the remaining varia…
- Who is the assignee on this patent?
- Pharmacopeia Drug Discovery, Merck Sharp & Dohme
- What technology area does this patent fall under?
- Primary CPC classification C07D207/09. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jun 23 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).