Substituted pyridine derivatives as FabI inhibitors

Patent metadata

Field	Value
Publication number	US-9062002-B2
Application number	US-201214361171-A
Country	US
Kind code	B2
Filing date	Nov 29, 2012
Priority date	Dec 2, 2011
Publication date	Jun 23, 2015
Grant date	Jun 23, 2015

Abstract

The present invention provides substituted pyridine derivatives of formula (I), which may be therapeutically useful as as anti-bacterial agents, more particularly FabI inhibitors. Formula (I) in which R1 to R5 and L have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention in diseases or disorder, in particular their use in diseases or disorder where there is an advantage anti-bacterial agents, more particularly FabI inhibitors. The present invention also provides methods for synthesizing and administering the FabI inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the FabI inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor.

First claim

We claim:

1. A compound of formula (I):

or a pharmaceutically acceptable salts and stereoisomer's thereof;

wherein;
R 1 is selected from an optionally substituted alkyl, amino, cycloalkyl, aryl, heterocyclyl, heteroaryl, heterocyclylalkyl or heteroarylalkyl;
R 2 is hydrogen; or
R 1 and R 2 may be taken together with the atoms to which they are attached…

Assignees

• Aurigene Discovery Tech Ltd
• Um Pharmauji Sdn Bhd

Inventors

• Takhi Mohamed
• Hosahalli Subramanya
• Panigrahi Sunil Kumar
• Mahadari Muni Kumar
• Kottam Chandrashekar Reddy
• Abd Rahman Noorsaadah
• Yusof Rohana

Classifications

• C07D401/14

  Chemistry & Metallurgy · mapped topic

• C07D471/04

  Chemistry & Metallurgy · mapped topic

• C07F5/025

  Chemistry & Metallurgy · mapped topic

• C07D213/75 Primary

  Chemistry & Metallurgy · mapped topic

• C07D471/14

  Chemistry & Metallurgy · mapped topic