C-Met Modulators and Methods of Use
US-2015376133-A1 · Dec 31, 2015 · US
US9061998B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9061998-B2 |
| Application number | US-201214003423-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 5, 2012 |
| Priority date | Mar 7, 2011 |
| Publication date | Jun 23, 2015 |
| Grant date | Jun 23, 2015 |
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The present invention relates to compounds of the formula (I), salts thereof, to pharmaceutical compositions containing them and their use in medicine. In particular, the invention relates to compounds as activators of AMPK.
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The invention claimed is: 1. A compound of formula (I) or a salt thereof: wherein: R 1 is a) a 5-membered heteroaryl optionally substituted with 1, 2, or 3 groups independently selected from —CH 3 , —OCH 3 , —OH, —CH 2 OH, —CF 3 , —OCF 3 , —CN, —CO 2 H, —CH 2 CO 2 H, —CONH 2 , —NH 2 and halogen; b) O-phenyl optionally substituted with a group selected from methyl,…
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