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Optogenetic probes for measuring membrane potential
US9057734B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9057734-B2 |
| Application number | US-201113818432-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 23, 2011 |
| Priority date | Aug 23, 2010 |
| Publication date | Jun 16, 2015 |
| Grant date | Jun 16, 2015 |
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Abstract
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The invention provides methods, cells and constructs for optical measurement of membrane potential. These methods can be used in cells that are not accessible to presently available methods using electrodes. The methods can be directed to, for example, high-throughput drug screening assays to determine agents that can affect membrane potential of a target cell.
First claim
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We claim: 1. A method for measuring membrane potential in a cell expressing a nucleic acid encoding a microbial rhodopsin protein, the method comprising the steps of: a. exciting, in vitro, at least one cell comprising a nucleic acid encoding a microbial rhodopsin protein with light of at least one wave length; and b. detecting, in vitro, at least one optical signal from the at least one cell, wherein the level of fluorescence emitted by the at least one cell compared to a refer…
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- C07K14/195Primary
Chemistry & Metallurgy · mapped topic
Physics · mapped topic
Physics · mapped topic
Chemistry & Metallurgy · mapped topic
- G01N33/6872Primary
Physics · mapped topic
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Frequently asked questions
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- What does patent US9057734B2 cover?
- The invention provides methods, cells and constructs for optical measurement of membrane potential. These methods can be used in cells that are not accessible to presently available methods using electrodes. The methods can be directed to, for example, high-throughput drug screening assays to determine agents that can affect membrane potential of a target cell.
- Who is the assignee on this patent?
- Cohen Adam E, Kralj Joel M, Douglass Adam D, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification C07K14/195. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jun 16 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).