Substrate independent copolymers for biofunctionalization
US-10100163-B2 · Oct 16, 2018 · US
US9051667B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9051667-B2 |
| Application number | US-92480307-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 26, 2007 |
| Priority date | Oct 26, 2007 |
| Publication date | Jun 9, 2015 |
| Grant date | Jun 9, 2015 |
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The present invention provides crosslinked epoxy-functional copolymer films and microarrays built from the crosslinked epoxy-functional copolymer films. Microarrays incorporating the copolymers include a substrate on which a film of the crosslinked epoxy-functional copolymer is disposed and target molecules bound to the copolymer film. The crosslinked polymer films are well-suited for use as scaffolds for target molecules in microarrays because they provide a high density of binding sites for the target molecules, are mechanically stable, and may be coated onto a wide range of substrates.
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What is claimed is: 1. A microarray comprising: (a) a substrate; and (b) a copolymer film disposed on the substrate, the copolymer film comprising a first set of polymerized monomers bearing an epoxy group reacted with a target molecule and a second set of polymerized photocrosslinked 2-(acryloyloxy)ethyl 2-methylacrylate monomers; wherein the copolymer film has a thickness of no more than about 100 nm and further wherein the thickness of the copolymer film is reduced by no mo…
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